T-Cell Receptors
AssigneesOspedale San Raffaele S.R.L., Università Vita-Salute San Raffaele
InventorsMaria Chiara Bonini, Eliana Ruggiero, Francesco Manfredi
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Abstract
The present invention provides a T-cell receptor (TCR) which binds to a Human Telomerase Reverse Transcriptase (hTERT) peptide or a Survivin peptide when presented by a major histocompatibility complex (MHC).
Claims51
A T-cell receptor (TCR) which binds to a Human Telomerase Reverse Transcriptase (hTERT) peptide when presented by a major histocompatibility complex (MHC), wherein the hTERT peptide comprises or consists of the amino acid sequence of SVLNYERARR (SEQ ID NO:
- 5).
A T-cell receptor (TCR) which binds to Survivin peptide when presented by a major histocompatibility complex (MHC), wherein the TCR comprises a CDR3α comprising the amino acid sequence of CALDRMDSSYKLIF (SEQ ID NO:
- 54) or a variant thereof having up to three amino acid substitutions, additions or deletions, and a CDR3β comprising the amino acid sequence of CASSYDODGEAFF (SEQ ID NO:
- 59) or a variant thereof having up to three amino acid substitutions, additions or deletions.
The TCR according to any preceding claim, wherein the TCR comprises one or more mutations at the α chain/β chain interface, such that when the α chain and the β chain are expressed in a T-cell, the frequency of mispairing between said chains and endogenous TCR α and β chains is reduced.
The TCR according to any preceding claim, wherein the TCR comprises a murinised constant region.
The TCR according to any preceding claim, wherein the TCR is a soluble TCR.
A polynucleotide encoding the α chain and/or the β chain of a TCR according to any preceding claim.
Dependencies are inferred from the claim text.