Stabilized pre-fusion piv3 f proteins
AssigneeMsd International Business GmbH
InventorsJohannes Petrus Maria Langedijk, Mark Johannes Gerardus Bakkers
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Abstract
The present invention relates to stabilized pre-fusion human parainfluenza virus 3 (HPIV3) F protein, and fragments thereof. The invention also relates to nucleic acid molecules encoding such proteins and fragments, and to the use of the proteins, fragments and nucleic acid molecules.
Claims19
A stabilized pre-fusion human parainfluenza virus 3 (HPIV3) F protein, comprising an F1 and an F2 domain comprising an amino acid sequence of the F1 and F2 domain of an F protein of an HPIV3 strain, wherein the amino acid residue at position 41 is P, and the amino acid residue at position 89 is M and the amino acid residue at position 222 is I, and the amino acid residue at position 168 is P, and the amino acid residue at position 470 is V and the amino acid residue at position 477 is V, and the amino acid residue at position 109 is Q, wherein the numbering of the amino acid positions is according to the numbering of amino acid residues in SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.