Vaccines against clostridioides difficile and methods of using the same

Abstract

Disclosed are vaccine compositions comprising polypeptides selected from Clostridioides difficile binary toxin B, Clostridioides difficile binary toxin A, a High Molecular Weight portion of Clostridioides difficile Surface Layer Protein A, and a Low Molecular Weight portion of Clostridioides difficile Surface Layer Protein A. Methods of preparing the vaccine composition, methods of preventing or reducing attachment of C. difficile to an epithelial cell, and methods of preventing or treating a condition caused by infection of Clostridioides difficile are also provided.

Dependencies are inferred from the claim text.