Compositions for use in treatment of acne
AssigneeSanofi Pasteur Limited
InventorsNadège ARNAUD BARBE, Danilo CASIMIRO, Andreas KARLSSON, Isabelle LEGASTELOIS, Noëlle MISTRETTA, Geneviève RENAULD, Bachra MOHAMED ROKBI, Khang TRAN, Monica WU
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Abstract
This invention relates to compositions (e.g. immunogenic compositions) which can be used to immunise against C. acnes. The compositions comprise C. acnes antigens and antigen combinations, used in the form of nucleic acids (e.g. mRNAs) encoding antigenic proteins or in the form of recombinant protein antigens.
Claims42
A nucleic acid comprising a nucleotide sequence encoding a modified Cutibacterium acnes (C. acnes) Christie-Atkins-Munch-Petersen factor 2 (CAMP2) polypeptide, wherein the modified C. acnes CAMP2 polypeptide comprises an amino acid sequence comprising a C. acnes CAMP2 polypeptide sequence and a transmembrane domain sequence.
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A modified C. acnes CAMP2 polypeptide having an amino acid sequence comprising a C. acnes CAMP2 polypeptide sequence and a transmembrane domain sequence.
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13-15. (canceled)
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A nucleic acid comprising a nucleotide sequence encoding a chimeric C. acnes DsA1/DsA2/PITP/CAMP2 polypeptide, wherein the chimeric C. acnes DsA1/DsA2/PITP/CAMP2 polypeptide comprises:
- (a) a chimeric C. acnes DsA1/DsA2 polypeptide;
- (b) an immunogenic fragment of a C. acnes PITP polypeptide, optionally wherein the immunogenic fragment comprises a ENFD of a C. acnes PITP polypeptide;
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- (c) a C. acnes CAMP2 polypeptide or an immunogenic fragment thereof.
A chimeric C. acnes DsA1/DsA2/PITP/CAMP2 polypeptide comprising:
- (a) a chimeric C. acnes DsA1/DsA2 polypeptide;
- (b) an immunogenic fragment of a C. acnes PITP polypeptide, optionally wherein the immunogenic fragment comprises a ENFD of a C. acnes PITP polypeptide;
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- (c) a C. acnes CAMP2 polypeptide or an immunogenic fragment thereof.
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35-40. (canceled)
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A composition, optionally an immunogenic composition, comprising a C. acnes CAMP2 polypeptide and one or more of:
- (i) a C. acnes DsA1 polypeptide,
- (ii) a C. acnes DsA2 polypeptide,
- (iii) a C. acnes PITP polypeptide,
- (iv) a chimeric C. acnes DsA1/DsA2 polypeptide, and
- (v) a chimeric C. acnes DsA1/DsA2/PITP polypeptide.
Dependencies are inferred from the claim text.