Metabolic inhibitors and methods of making and using thereof

A compound comprising a structure represented by Formula I, or a pharmaceutically acceptable salt thereof:

• wherein
• A comprises a mitochondrial targeting moiety;
• Z comprises a lipid chain;
• R1 and R2 are independently hydrogen, a substituted or unsubstituted C1-C10 alkyl, a glycolysis inhibitor, a glutamine oxidation inhibitor, or a fatty acid inhibitor, wherein at least one of R1 or R2 is a glycolysis inhibitor, a glutamine oxidation inhibitor, or a fatty acid inhibitor;
• R3 is a substituted or unsubstituted C1-C10 alkylene;
• L1 is a substituted or unsubstituted alkylene, a carbonyl, an ester, an amide, a carbamate ester, an amine, an ether, a carbonate ester, a thioether, a thioester, or a urea;
• each L2 is independently a direct bond, a C1-C4 alkylene, or —RaX—, wherein Ra is a C0-C4 alkylene and X is a detectable-group.