1h-pyrazole analogues and methods and uses thereof

A compound having a structure of Formula I:

• a pharmaceutically-acceptable salt thereof, hydrate thereof, solvate thereof tautomer thereof, geometric isomer thereof, enantiomer thereof, diastereomer thereof, N-oxide thereof, metabolite thereof, isotopomer thereof, isotopologue thereof, prodrug thereof or combination thereof,
• wherein:
• X1 is selected from —BR8R9 or —BR10R11R12;
• R1 to R7, R10, R11, and R12 are each independently selected from H, a halo group, a hydroxyl group, a cyano group, a nitro group, a thiol group, a sulfonyl group, a sulfate group, a substituted or unsubstituted amino group, a substituted or unsubstituted hydrocarbon group, a substituted or unsubstituted heterogeneous group, —BR13R14, —BR15R16R17, a substituted or unsubstituted carbocyclic group, a substituted or unsubstituted heterocyclic group, a substituted or unsubstituted aromatic group, or a substituted or unsubstituted heteroaromatic group, wherein R13 to R17 are each independently selected from H, a halo group, a hydroxyl group, a cyano group, a substituted or unsubstituted amino group, a substituted or unsubstituted hydrocarbon group, a substituted or unsubstituted heterogeneous group, a substituted or unsubstituted carbocyclic group, a substituted or unsubstituted heterocyclic group, a substituted or unsubstituted aromatic group, or a substituted or unsubstituted heteroaromatic group or R13 and R14 are taken together to form a substituted or unsubstituted carbocyclic group, or a substituted or unsubstituted heterocyclic group;
• and
• R8 and R9 are each independently selected from H, a halo group, a hydroxyl group, a cyano group, a nitro group, a thiol group, a sulfonyl group, a sulfate group, a substituted or unsubstituted amino group, a substituted or unsubstituted hydrocarbon group, a substituted or unsubstituted heterogeneous group, a substituted or unsubstituted carbocyclic group, a substituted or unsubstituted heterocyclic group, a substituted or unsubstituted aromatic group, a substituted or unsubstituted heteroaromatic group, or are taken together to form a substituted or unsubstituted carbocyclic group, or a substituted or unsubstituted heterocyclic group.