Transdermal permeation enhancing composition and application thereof in timolol preparation
AssigneeWuhan Conform Pharmaceutical Co., Ltd.
InventorsXiaoshun ZHOU, Dongsheng MOU, Guofu TONG, Zhimei LIU, Yuan LIAO, Rongli HE, Wenshuang LIU
Life of this patent
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Abstract
A transdermal permeation enhancing composition, consisting of 65 wt %-98 wt % of white vaseline and 2 wt %-35 wt % of wax substance. The wax substance is selected from one or more of light liquid paraffin and white beeswax. The transdermal permeation enhancing composition is used for improving the transdermal absorption effect of timolol.
Claims3
A method of preparing of a composition for treating infantile hemangiomas in a subject, comprising mixing timolol as an active ingredient with a transdermal permeation enhancing composition to form the composition,
- wherein the transdermal permeation enhancing composition consists of white Vaseline, a light liquid paraffin and white beeswax, wherein an amount of the white Vaseline is from 68 wt % to 93 wt %, an amount of the light liquid paraffin is from 5 wt % to 30 wt %, and the amount of the white beeswax is from 2 wt % to 8 wt %, and
- a concentration of timolol is 0.1 wt % to 3 wt %.
Dependencies are inferred from the claim text.