Use of sivelestat in analgesia
AssigneeShanghai Huilun Pharmaceutical Co., Ltd.
InventorWenhua Li
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Abstract
The present invention relates to a use of sivelestat in analgesia, and in particular to a use of sivelestat or a salt thereof alone or in combination with an opioid in the preparation of a drug for treating or relieving pain, especially postoperative pain or post-traumatic pain. Sivelestat has a long-lasting analgesic effect in the treatment of postoperative pain or post-traumatic pain, and can generate a significant synergistic effect when used in combination with the opioid. The combination of sivelestat and the opioid can significantly reduce the dosage of the opioid, and can further prolong the analgesia time.
Claims10
A method for treating or alleviating posttraumatic pain or postoperative pain in a subject in need thereof, comprising administering a therapeutically effective amount of sivelestat or a pharmaceutically acceptable salt thereof in combination with an opioid drug.
A combination product comprising the following components:
- (1) sivelestat or a pharmaceutically acceptable salt thereof;
- and
- (2) a full agonist of μ-opioid receptor;
- wherein the full agonist of μ-opioid receptor is selected from morphine, fentanyl, remifentanil, pethidine, oxycodone, and hydromorphone.
(canceled)
A method for treating or alleviating posttraumatic pain or postoperative pain in a subject in need thereof, comprising administering a therapeutically effective amount of sivelestat or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.