Compositions and methods for delivering cargo to cells
AssigneeThe University of North Carolina at Chapel Hill
InventorsOwen Fenton, JR., Yutian Ma, Palas Tiwade
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Abstract
Disclosed herein are functionalized polyethylenimine compounds for use as nanoparticles. Methods of making the compounds and nanoparticles comprising a cargo and methods of delivering a nanoparticle comprising a cargo are provided. The nanoparticles of the present invention can be utilized in methods of delivering cargo in a tissue specific manner, providing low toxicity and efficient release of cargo in the cell.
Claims29
A polymer comprising a plurality of amine groups, wherein at least one amine group comprises a nitrogen atom directly bonded to a functional group according to Formula I:
- wherein R is C6 to C18 alkanyl, alkenyl or alkynyl.
A polymer formed by reacting a polyethyleneimine with an alkynoate according to Formula II:
- to thereby form a functionalized PEI polymer,
- wherein R is C6 to C18 alkanyl, alkenyl or alkynyl.
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Dependencies are inferred from the claim text.