Pharmaceutical formulations comprising naltrexone and/or bupropion
AssigneeNalpropion Pharmaceuticals LLC
InventorsRob Churchill, Aaron Chesnut
Life of this patent
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Abstract
Described are pharmaceutical formulations comprising naltrexone and/or bupropion. Such pharmaceutical formulations can comprise extended-release, multilayer beads. Also described are methods of administering such formulations, such as for the treatment of overweight or obesity.
Claims6
An oral dosage form comprising naltrexone and bupropion, wherein the oral dosage form comprises a naltrexone extended-release formulation having an in vitro naltrexone dissolution profile in a dissolution test of USP Apparatus 1 Basket Method at 100 rpm in a dissolution medium of water at 37° C. of:
- 2% to 30% of the naltrexone released in one hour;
- 10% to 60% of the naltrexone released in two hours;
- and
- at least 50% of the naltrexone released in four hours.
An oral dosage form comprising naltrexone and bupropion, wherein the oral dosage form comprises a bupropion extended-release formulation having an in vitro bupropion dissolution profile in a dissolution test of USP Apparatus 1 Basket Method at 100 rpm in a dissolution medium of water at 37° C. of:
- 2% to 30% of the bupropion released in one hour;
- 10% to 60% of the bupropion released in two hours;
- and
- at least 50% of the bupropion released in four hours.
An oral dosage form comprising naltrexone and bupropion, wherein the oral dosage form comprises a naltrexone extended-release formulation having an in vitro naltrexone dissolution profile in a dissolution test of USP Apparatus 1 Basket Method at 100 rpm in a dissolution medium of water at 37° C. of:
- 2% to 30% of the naltrexone released in one hour;
- 10% to 60% of the naltrexone released in two hours;
- and
- at least 50% of the naltrexone released in four hours;
- and
- wherein the oral dosage form comprises a bupropion extended-release formulation having an in vitro bupropion dissolution profile in a dissolution test of USP Apparatus 1 Basket Method at 100 rpm in a dissolution medium of water at 37° C. of:
- 2% to 30% of the bupropion released in one hour;
- 10% to 60% of the bupropion released in two hours;
- and
- at least 50% of the bupropion released in four hours.
Dependencies are inferred from the claim text.