GLUTATHIONE-COATED GOLD NANOPARTICLES FUNCTIONALIZED WITH LITHIUM (LiG-AuNPs) AND USES THEREOF FOR THE MODULATION OF GLYCOGEN SYNTHASE KINASE - 3 ACTIVITY

Abstract

The present invention relates to a method for the production of gold nanoparticles (AuNPs) coated with glutathione and Li+ ions, hereinafter designated as LiG-AuNPs, to a method for the preparation of aggregates of said nanoparticles and to the use of said nanoparticles, aggregates or compositions thereof which comprise them for therapeutic use. LiG-AuNPs then are an effective instrument in inhibiting GSK-3 and its downstream molecular targets, while keeping the lithium extracellular concentration levels below the systemic toxicity threshold (1.5 mEq/L), and exerting an antioxidant action by means of the glutathione present on their surface.

Dependencies are inferred from the claim text.