Compositions and techniques for treatment of polycystic ovarian syndrome (pcos) and endometriosis

A composition, comprising:

• a poloxamer;
• a stabilization polymer;
• and
• an active ingredient for treating polycystic ovarian syndrome (PCOS) and/or treating endometriosis, wherein the composition is made by a process comprising forming a composition comprising the poloxamer, the stabilization polymer, and the active ingredient, and removing air from the composition.

An implantable drug delivery device comprising:

• an inner core comprising at least one active pharmaceutical ingredient distributed throughout a first water-insoluble polymer, wherein the at least one active pharmaceutical ingredient comprises melatonin or a melatonin receptor agonist or pharmaceutically acceptable salt thereof;
• an intermediate coating positioned around the inner core, said intermediate coating comprising an acrylate polymer;
• and an outer coating positioned around the intermediate coating, said outer coating comprising a second water-insoluble polymer;
• wherein the acrylate polymer is formed from one or more monomers of formula (I):
• wherein R1 is selected from H, alkyl, alkenyl, alkynyl, or aryl;
• and R2 is selected from H or alkyl.