Systems and methods for invasive diagnostic planning

A system for implementing invasive diagnostic testing in advance of a procedure, comprising:

• a memory for storing a plurality of instructions;
• processor circuitry that couples with the memory and is configured to execute the instructions to:
• retrieve at least one image, the image including at least a portion of a blood vessel;
• extract from the at least one image a plurality of cross-sectional profiles at distinct locations along the blood vessel;
• generate a hemodynamic model based on the at least one image and at least partially based on the cross-sectional profiles, the hemodynamic model modeling blood flow at each of the distinct locations for which cross-sectional profiles have been extracted;
• extract, from the at least one image, a determination of plaque features;
• generate or retrieve an initial treatment plan based at least partially on the hemodynamic model and the determined plaque features;
• and
• determine, based on the hemodynamic model and the determination of the plaque features that a defined invasive diagnostic test is likely to change the initial treatment plan.