Medication therapy management system and methods

A computer-implemented method comprising:

• retrieving clinical data from an electronic health record and genomic data from a genomic service, the clinical data and the genomic data corresponding to a patient, wherein the electronic health record is accessed via an HL7- or FHIR-compatible interface;
• forming a longitudinal data record based on the clinical data and the genomic data;
• normalizing the clinical data and the genomic data to an ontology such that the clinical data and the genomic data are codified into diagnoses, medications, and genomic annotations for lifecycle analysis;
• defining, for each diagnosis, a diagnosis lifecycle object having states that include at least a baseline state, an active treatment state, and a managed state;
• establishing a baseline for the diagnosis lifecycle object from the longitudinal data for that diagnosis;
• detecting variances by comparing protocol behaviors and rule-based thresholds with actual patient data received over time, the actual patient data including at least one of adherence responses, questionnaire inputs, connected-device signals, and laboratory or biomarker measurements;
• and
• evaluating, using a rule-based diagnosis lifecycle model, treatment response for the diagnosis lifecycle object based on adherence state transitions together with clinical or genomic indicators, and transitioning the diagnosis lifecycle object to a corresponding lifecycle state.