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US 2026/0229308 A1Published application
Tumorigenicity scoring for cancer vaccine development and medical decision making
AssigneeNEC Laboratories America, Inc.
InventorsJonathan Warrell, Renqiang Min
Life of this patent
Estimating the term…
Abstract
Methods and systems for vaccine generation include determining genome sequence for target. A tumorigenicity score is determined for neoantigens of the target using a variance analysis in a linear random effects model. The neoantigens are ranked based on the tumorigenicity score. A vaccine is generated based on the ranked neoantigens.
Claims20
A computer-implemented method for vaccine generation, comprising:
- determining genome sequence for target;
- determining a tumorigenicity score for a plurality of neoantigens of the target using a variance analysis in a linear random effects model;
- ranking the plurality of neoantigens based on the tumorigenicity score;
- and
- generating a vaccine based on the ranked neoantigens.
2 more elements
A system for vaccine generation, comprising:
- a hardware processor;
- and
- a memory that stores a computer program which, when executed by the hardware processor, causes the hardware processor to:
- determine genome sequence for target;
- determine a tumorigenicity score for a plurality of neoantigens of the target using a variance analysis in a linear random effects model;
- rank the plurality of neoantigens based on the tumorigenicity score;
- and
- generate a vaccine based on the ranked neoantigens.
5 more elements
Dependencies are inferred from the claim text.