Hyper-throughput, multiplex, single molecule imaging platform

Abstract

A total internal reflection fluorescence microscopy system includes a light source, a light movement apparatus, such as a vibration motor or a 2D scanning device, coupled to an output of the light source, such as an RGB laser, for receiving a first light signal generated by the light source, the light movement apparatus being structured and configured to generate a second light signal from the first light signal, the second light signal being a light signal that moves in at least 2 dimensions, a prism structured to receive the second light signal and direct the second light signal to a sample, a lens assembly structured to receive an emission light signal emitted from the sample in response to the second light signal, and one or more light detectors, such as one or more industry grade cameras, coupled the lens assembly for receiving the emission light signal. WO

Dependencies are inferred from the claim text.