System and method for improving nmr measurement results for a sample

A computer system for improving an NMR measurement result obtained by an NMR spectrometer for a sample, comprising:

• a data interface adapted to receive a magnetic field map for an actual main magnetic field of the NMR spectrometer with the sample being located at its measuring position, wherein the magnetic field map is obtained from a measurement of a deviation of the actual magnetic field from an ideal homogenous field B0 as a function of spatial location in the sample, wherein magnetic field measurement points are taken at z-intervals along a z-direction of the sample, and to receive a time domain NMR measurement of the sample;
• a function generator module adapted to compute, in a frequency domain, a correction function for the NMR measurement based on the received magnetic field map, by determining, for each of a plurality of predefined frequency intervals which covers a frequency range with B0 deviations, a total length of z-intervals with frequency values in the respective frequency interval, wherein the determined total length is the value of the correction function for the respective frequency interval;
• a frequency-to-time-domain transformation module adapted to transform the correction function into the time domain;
• a correction module adapted to divide the time domain NMR measurement by the transformed correction function to obtain a corrected time domain NMR measurement curve;
• and
• a time-to-frequency-domain transformation module adapted to transform the corrected time domain NMR measurement curve into the frequency domain to obtain an NMR spectrum of the sample with symmetrized peaks and overlapping peaks being resolved.

A computer program product for improving an NMR measurement result obtained by an NMR spectrometer for a sample, comprising a non-transitory computer-readable medium storing instructions that, when loaded into a memory of a computing device and processed by at least one processor of the computing device, cause the computing device to:

• receive a magnetic field map for an actual main magnetic field of the NMR spectrometer with the sample being located at its measuring position, wherein the magnetic field map is obtained from a measurement of a deviation of the actual magnetic field from an ideal homogenous field B0 as a function of spatial location in the sample, wherein magnetic field measurement points are taken at z-intervals along a z-direction of the sample;
• receive a time domain NMR measurement of the sample;
• compute, in a frequency domain, a correction function for the NMR measurement based on the received magnetic field map, by determining, for each of a plurality of predefined frequency intervals which covers a frequency range with B0 deviations, a total length of z-intervals with frequency values in the respective frequency interval, wherein the determined total length is the value of the correction function for the respective frequency interval;
• transform the correction function into the time domain;
• divide the time domain NMR measurement by the transformed correction function to obtain a corrected time domain NMR measurement curve;
• and
• transform the corrected time domain NMR measurement curve into the frequency domain to obtain an NMR spectrum of the sample with symmetrized peaks and overlapping peaks being resolved.