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AssigneeFlagship Pioneering Innovations VI, LLC
InventorsVinidhra Mani, Erica Gabrielle Weinstein, Yann Paul Guy Régis Echelard, Avak Kahvejian, Patrick Shannon Pendergrast, Tamara Ouspenskaia, Gabriel Humphrey Billings, Vlad Grishkevich, Sungmin Baek
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The disclosure provides, in various embodiments, compositions, such as polypeptides, polynucleotides, gene editing system, small molecules, vectors or host cells, that comprises and/or modulate expression or activity of immune regulation-associated proteins. The disclosure also provides, in various embodiments, methods of treating aging, senescence, fibrosis, autoimmunity, cancer, an infection, and/or an immunological disease using an agent that comprises and/or modulates expression or activity of an immune regulation-associated protein and methods of identifying said agent.
An agent that comprises and/or modulates the expression or activity of a target protein identified in the Sequence Listing, or a variant thereof.
A method of predicting a likelihood of developing a disease or condition in a subject, comprising quantifying an expression or activity of a target protein identified in the Sequence Listing in a sample from the subject, wherein the level of expression or activity of the target protein in the sample is indicative of the likelihood of developing cancer in the subject, wherein the disease or condition is selected from aging, senescence, fibrosis, autoimmunity, cancer, an infection, an immunological disease, or a combination thereof.
A method of preparing a sample that is useful for detecting a likelihood of developing a disease or condition in a subject, comprising:
A method for identifying an agent that modulates the expression or activity of a target protein identified in the Sequence Listing, or a variant thereof, comprising:
Dependencies are inferred from the claim text.