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AssigneesUniversity of Washington, Seattle Children's Hospital d/b/a Seattle Children's Research Institute
InventorsSuzie Hwang Pun, Emmeline Cheng, Nataly Kacherovsky, Yuan-Che Wu, Michael C. Jensen
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Various implementations described herein relate to oligonucleotides that specifically bind L-selectin. According to some implementations, oligonucleotides are conjugated to a support, a tag, a linker, or a drug. An example method includes exposing a solution of cells to the oligonucleotides and isolating cells that express L-selectin from the solution of cells, wherein the cells that express L-selectin are bound to the oligonucleotides. The example method further includes applying a reversal construct to release the cells that express L-selectin from the oligonucleotides. Example methods and compositions described herein can be used for cell selection, diagnostic, therapeutic, or research purposes.
1-102. (canceled)
A method of cell sorting, the method comprising:
An oligonucleotide that specifically binds L-selectin, the oligonucleotide comprising a sequence having at least 70% sequence identity to the sequence as set forth in SEQ ID NO:
A method of treating a subject in need thereof, the method comprising:
Dependencies are inferred from the claim text.