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US 2026/0227397 A1Published application
Methods and systems of profiling with biological computing cells
AssigneeXeno Cell Innovations S.R.O.
InventorsDaniel GEORGIEV, Martin CIENCIALA, Hynek KASL, Laura BERNE
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Abstract
Provided herein are biological computing methods, systems, and kits, which can include computing units that can process input signals to produce output signals. Computing units can include cells and/or molecules that can convert biological signals into output signals that can provide information about the input sample.
Claims78
A method of detecting presence or absence of an output signal indicative of a characteristic of an input sample, comprising:
- (a) contacting at least one sample object derived from the input sample with a Reaction Reagent comprising at least one computing unit (CU) and with a Reaction Medium, wherein the at least one CU is configured to interact with the at least one sample object;
- (b) incubating (a) for a sufficient amount of time in an incubator for the output signal to be generated;
- (c) adding a readout reagent comprising a reporter entity to (b), wherein the reporter entity generates the output signal;
- and
- (d) measuring the output signal, wherein the output signal is directly proportional to the amount of the at least one sample object derived from the input sample, thereby detecting the presence or absence of the output signal indicative of the characteristic of the input sample.
2 more elements
A system for biological computing, comprising:
- (a) at least one sample object derived from an input sample;
- (b) a Reaction Reagent comprising at least one computing unit (CU) configured to interact with the at least one sample object;
- (c) a Reaction Medium;
- and
- (d) a readout reagent comprising a reporter entity and a reporter buffer.
2 more elements
A kit for biological computing, comprising:
- (a) one or more reaction tubes comprising Reaction Reagent;
- (b) one or more master tubes comprising Reaction Medium;
- (c) a readout reagent comprising a reporter entity and a reporter buffer;
- and
- (d) an instruction for use of the kit.
2 more elements
Dependencies are inferred from the claim text.