Improved method and system for determining efficacies for one or more pharmaceutical drugs for a plurality of medical indications
AssigneePreComb Therapeutics AG
InventorsOlivier Mauti, Peter Steiner, Jens Kelm
Life of this patent
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Abstract
The present invention relates to an improved method for determining efficacies of one or more drugs for a plurality of indications, based on data obtained from a plurality of patients using standardized and integrated testing systems, as well as respective systems for performing the method, and the analysis and storage of the data as generated.
Claims15
A method for determining efficacies for one or more pharmaceutical drugs for a plurality of medical indications, the method comprising
- i) obtaining raw data regarding an effect of one or more pharmaceutical drugs for a plurality of patients that are afflicted by at least one of a plurality of medical indications, at a plurality of separate testing centers, and using one or more standardized testing systems,
- wherein the obtaining comprises the steps of:
- providing cells from at least one patient-derived tissue sample;
- using one of the standardized testing systems, generating 3D microtissues in the standardized testing system based on the cells as provided;
- contacting the 3D microtissues as generated with the one or more pharmaceutical drugs to be tested;
- collecting the raw data regarding an effect of the one or more pharmaceutical drugs on the 3D microtissues;
- and
- ii) transmitting the raw data as collected to a centralized server;
- and
- iii) based on the raw effect data as received at the centralized server, determining efficacies for the one or more pharmaceutical drugs as tested for at least one of the medical indications, at the centralized server, and selecting the pharmaceutical drug as determined having the highest efficacy for the at least one medical indication, wherein the efficacy is patient-specific.
A system for determining efficacies for one or more pharmaceutical drugs for a plurality of medical indications, the system comprising:
- one or more standardized testing positioned at one or more local testing centers in one of a same location and different locations, the one or more standardized testing system configured to:
- at least one of receive and generate cells from at least one patient-derived tissue sample;
- generate 3D microtissues in said system based on the cells;
- contact the 3D microtissues as generated with the one or more pharmaceutical drugs to be tested;
- collect raw data regarding an effect of the one or more pharmaceutical drugs on the 3D microtissues, wherein the raw data is standardized and autonomously generated;
- and
- transmit the raw data as collected to a centralized server;
- the centralized server, connected to said at least on standardized testing system, configured to determine efficacies for the one or more pharmaceutical drugs as tested for at least one of the medical indication;
- means for selecting the pharmaceutical drug as determined having the highest efficacy for the at least one medical indication, wherein the means are configured to select a combination of pharmaceutical drugs that are determined as having the highest efficacy for the at least one medical indication.
Dependencies are inferred from the claim text.