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US 2026/0226562 A1Published application
Extracellular vesicles for treatment and diagnosis
AssigneeExostem Biotec Ltd.
InventorAharon BRODIE
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Abstract
The present invention provides methods of detecting a cellular state in a subject, comprising providing a sample from the subject comprising extracellular vesicles (EVs), isolating a population of EVs originating from a tissue or cell type from the sample, and determining in the population of EVs the presence of at least one factor indicative of the cellular state, wherein the presence of the at least one factor indicates the cellular state is present in the tissue or cell type, thereby detecting a cellular state in a subject.
Claims20
method of detecting an adverse cellular state in a subject in need thereof, the method comprising:
- (i) providing a sample obtained from said subject, said sample comprising extracellular vesicles (EVs);
- (ii) isolating from said sample a population of EVs originating from brain astrocytes, microglia, neurons, heart, kidney, liver or lung by the expression of at least one EV surface marker selected from those provided in Table 1;
- and
- (iii) determining in said population of EVs a presence of at least one factor indicative of said adverse cellular state;
- wherein said presence of said at least one factor indicates said adverse cellular state is present in said tissue or cell type;
- thereby detecting an adverse cellular state in a subject in need thereof.
3 more elements
Dependencies are inferred from the claim text.