Cancer subtype identifier and method for classifying tumors

A method for predicting the prognosis for a subject suffering from cancer the method comprising using a cancer subtype identifier based on PSI values based on an occurrence of at least one mutually exclusive exon usage event, and/or expression of small nuclear RNAs and/or expression of protein-coding genes comprising the steps:

• a) collecting a sample from a tumor and/or body fluid and/or body excretion of a subject;
• b) determining at least one of
• the PSI values based on the occurrence of at least one mutually exclusive exon usage event,
• deregulation of the expression of small nuclear RNAs,
• expression of subtype predictive protein-coding genes, and
• combinations thereof;
• c) converting of values of step b) into a rating scale to indicate the disease prognosis.

A method for administering an anti tumor treatment to a subject suffering from cancer the method comprising using a cancer subtype identifier based on PSI values based on an occurrence of at least one mutually exclusive exon event, and/or the deregulation of expression of small nuclear RNAs and/or deregulation of expression of subtype predictive protein-coding genes comprising the steps:

• a′) collecting a sample from a tumor and/or body fluid and/or body excretion of a subject;
• b′) determining at least one of
• the PSI values based on the occurrence of at least one mutually exclusive exon usage event,
• deregulation of the expression of small nuclear RNAs,
• expression of subtype predictive protein-coding genes,
• combinations thereof;
• c′) conversion of the values of step b) into a rating scale to indicate the disease prognosis by classifying the tumors as MXE1 subtype or MXE2 subtype;
• d′) subjecting the subject to an anti tumor treatment if the rating scale indicates that the subject is likely to experience an increased progression of the disease.