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US 2026/0226550 A1Published application
Methods and systems for treatment determination and analysis
AssigneeAMPEL BioSolutions, LLC
InventorsPeter Lipsky, Prathyusha Bachali, Andrea Daamen, Amrie Grammer
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Abstract
The present invention provides methods for monitoring treatment of a subject. The subject may be suffering from an autoimmune condition (e.g. lupus). The methods may comprise analyzing expression levels of genes of a plurality of gene sets to determine an endotype. A treatment dose may be determined based on the endotype.
Claims21
1-45. (canceled)
A method of monitoring treatment of a subject, the method comprising:
- (a) providing a first sample from the subject having received a first dose of a first cereblon E3 ligase modulator;
- (b) assaying the first sample to determine expression levels of genes of a plurality of gene sets in the first sample, wherein the plurality of gene sets comprises at least one gene set comprising at least 30% of genes of a gene set from Table 1;
- (c) determining a first endotype of the subject, based at least in part on the expression levels determined in (b);
- and
- (d) based at least in part on the first endotype, determining a second dose of a second cereblon E3 ligase modulator for administration to the subject.
2 more elements
Dependencies are inferred from the claim text.