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US 2026/0226540 A1Published application
Sequencing reagents
AssigneeUltima Genomics, Inc.
InventorsCharles FRANCAVILLA, Daniel MAZUR, Abhisek RAY, Maodie WANG, Dancan NJERI, Theo NIKIFOROV, Emma ZANARDI, Kevin HEINEMANN
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Abstract
Provided herein are sequencing reagents. The sequencing reagent may comprise a labelling reagent or a labelled substrate comprising a polyethylene glycol (PEG) polymer. The sequencing reagent may comprise a labelling reagent or a labelled substrate comprising a protein.
Claims21
A sequencing reagent, comprising:
- a nucleotide;
- a linker;
- a fluorescent dye moiety;
- and
- a dendrimer comprising a plurality of dendrimer branches each comprising a repeating number of polyethylene glycol (PEG) or hydroxyproline, wherein said linker is attached to a nucleobase of said nucleotide and said dendrimer, and wherein (i) two dendrimer branches of said plurality of dendrimer branches are attached to a dendrimer core of said dendrimer and said fluorescent dye moiety is disposed between said two dendrimer branches and attached to said dendrimer core or (ii) two nth order dendrimer branches of said plurality of dendrimer branches are attached to a (n−1)th dendrimer branch of said dendrimer and said fluorescent dye moiety is disposed between said two nth order dendrimer branches and attached to said (n−1)th dendrimer branch.
2 more elements
A sequencing reagent, comprising:
- a nucleotide;
- a linker;
- a fluorescent dye moiety;
- and
- a dendrimer comprising a plurality of dendrimer branches each comprising a repeating number of a polymer, polyethylene glycol (PEG), or hydroxyproline, wherein said linker is attached to a nucleobase of said nucleotide and said dendrimer, and wherein said fluorescent dye moiety is attached to a distal end of a highest order dendrimer branch of said plurality of dendrimer branches relative to a dendrimer core of said dendrimer.
2 more elements
-79. (canceled)
Dependencies are inferred from the claim text.