Production of omega-hydroxy fatty acids and their derivatives using engineered cells
AssigneeNutrition & Bioscien USA 4, Inc.
InventorsZACHARY BAER, Michael W. BOSTICK, Zhongqiang CHEN, Xiaochun FAN, Min QI, Yehong Jamie WANG, Zhixiong XUE, Quinn Qun zhu
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Abstract
Methods for producing macrocyclic molecules, particularly omega-hydroxy fatty acids, are described. The methods involve the use of engineered cells having modified biochemical pathways that allow them to efficient produce omega-hydroxy fatty acids from C16 precursors. The resulting omega-hydroxy fatty acids are useful for the production of perfumes and other scented consumer products.
Claims10
Genetically engineered cells with reduced fatty alcohol oxidase activity and reduced fatty acid β-oxidation compared to otherwise identical parental cells, wherein the genetically engineered cells are engineered to reduce or eliminate expression or activity of peroxisomal β-oxidation multifunctional enzyme type 2 (MFE2) and to reduce or eliminate expression or activity of endogenous fatty alcohol oxidase.
Dependencies are inferred from the claim text.