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US 2026/0226485 A1Published application
Methods for producing high-level squalene
AssigneeMassachusetts Institute of Technology
InventorsGregory Stephanopoulos, Yongshuo Ma
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Abstract
Aspects of the present disclosure relate to modified yeast cells capable of producing increased quantities of squalene as compared to unmodified yeast cells and methods of using the same.
Claims31
A modified yeast cell, comprising:
- a first set of heterologous polynucleotides encoding a first set of enzymes of the mevalonate pathway, wherein one or more of the first set of enzymes of the mevalonate pathway is/are linked to a peroxisomal targeting signal;
- a first heterologous polynucleotide encoding a lipase;
- and
- a second set of heterologous polynucleotides encoding a second set of enzymes having triacylglycerol synthesis activity.
1 more element
Dependencies are inferred from the claim text.