Cutibacterium acnes recombinant phages, method of production and uses thereof
AssigneeEligo Bioscience
InventorsAymeric LEVEAU, Ines CANADAS BLASCO, Aurelie MATHIEU, Antoine DECRULLE
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Abstract
The invention relates to C. acnes strains carrying DNA vectors for the production of recombinant C. acnes phages. The invention encompasses a C. acnes producer cell carrying DNA vectors, with a template for recombination with C. acnes phage genome leading to the insertion of a gene of interest, for the production of recombinant phages that can lead to the transgene expression into C. acnes infected by the recombinant phage. The invention encompasses, C. acnes strains containing these vectors, C. acnes recombinant phages and methods of using these recombinant phages.
Claims14
A method for expressing a transgene comprising transducing a C. acnes with a recombinant C. acnes phage comprising at least one transgene, wherein said transgene encodes a human protein selected from an antibody, a protein that binds non-covalently to a target, a receptor binding protein, a blood factor, an enzyme, a growth factor, a hormone, an interferon, and a cytokine.
Dependencies are inferred from the claim text.