Compositions and Methods and Targeting a Splice Variant of the Regulatory Subunit of Myosin Phosphatase (MP) for Therapeutic Gain in Hypertension and Heart Failure
AssigneesUniversity of Maryland, Baltimore, The United States Government as represented by the Department of Veterans Affairs
InventorSteven Andrew Fisher
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Abstract
The present invention provides an oligomer capable of binding to a target site of precursor messenger RNA (pre-mRNA) of myosin phosphatase target subunit (Mypt1) in cells, wherein binding of the oligomer to the target site of the pre-mRNA suppresses splicing of exon 24 of myosin phosphatase target subunit (Mypt1) in cells. Pharmaceutical compositions comprising the same and methods of use thereof are further provided.
Claims23
An oligomer capable of binding to a target site of precursor messenger RNA (pre-mRNA) of myosin phosphatase target subunit (Mypt1) in cells, wherein binding of the oligomer to the target site of the pre-mRNA suppresses splicing of exon 24 of myosin phosphatase target subunit (Mypt1) in cells.
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Dependencies are inferred from the claim text.