Reverse transcriptase mutants and uses thereof
OwnerSarah Franz Beaudoin, Christopher Anthony Vakulskasinventors
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Abstract
The present disclosure provides Moloney murine leukemia virus (MMLV) reverse transcriptase (RTase) variants. The present disclosure further provides amino acid positions for mutagenesis of MMLV RTase as well as nucleic acids, kits, compositions, fusion proteins, and methods including MMLV RTase variants.
Claims17
An isolated Moloney murine leukemia virus (MMLV) reverse transcriptase (RTase) mutant comprising an amino acid sequence as set forth in any of SEQ ID NOs:
- 278-432.
An MMLV RTase variant comprising a substitution at a position corresponding to least one of position 9, position 157, position 159, position 173, position 287, position 333, position 433, position 435, position 467, position 490, position 502, position 629, or position 646 of any of SEQ ID NOs:
- 275-277.
Dependencies are inferred from the claim text.