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US 2026/0226428 A1Published application
Microorganism having enhanced activity of 3-methyl-2-oxobutanoate hydroxymethyltransferase and uses thereof
AssigneeCj Cheiljedang Corporation
InventorsYee-Seul SO, Kwang Soo SHIN, Jihyun SHIM, Kwang Woo LEE, Yeon-Jae JANG
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Abstract
A 3-methyl-2-oxobutanoate hydroxymethyltransferase variant, a microorganism having enhanced activity of 3-methyl-2-oxobutanoate hydroxymethyltransferase, a composition for producing pantothenic acid and/or pantoic acid comprising the microorganism, and a method for preparing pantothenic acid and/or pantoic acid comprising culturing the microorganism are provided.
Claims10
A microorganism producing pantothenic acid or pantoic acid, comprising
- a polypeptide comprising an amino acid sequence having at least 95% sequence identity to SEQ ID NO:
- 37 or a polynucleotide encoding the polypeptide,
- wherein the amino acid at the position corresponding to position 159 of the polypeptide of SEQ ID NO:
- 37 is substituted with another amino acid, and
- wherein the polypeptide has 3-methyl-2-oxobutanoate hydroxymethyltransferase activity.
2 more elements
Dependencies are inferred from the claim text.