Test system comprising stably cyp-transfected or transduced mammalian cells
AssigneesBrandenburgische Technische Universität Cottbus-Senftenberg, Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.
InventorsJan-Heiner KÜPPER, Christian SCHULZ
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Abstract
The present invention relates to a mammalian cell or cell line, preferably a CHO cell, containing polynucleotides stably integrated into the genome after transformation, encoding at least one P450 cytochrome (CYP) and NADPH-P450 cytochrome (CPR, POR), their use, and a test system obtainable therefrom, preferably by providing microsomes (fractions) or suspension cells.
Claims16
A mammalian cell comprising, after transfection or transduction, polynucleotides stably integrated into the genome encoding at least one cytochrome P450 and NADPH cytochrome P450 oxidoreductase.
Dependencies are inferred from the claim text.