Oncolytic Viruses as Therapeutic Agents for Treating Cancer
AssigneeImmVirX Pty Ltd
InventorDarren Shafren
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Abstract
The present invention relates to compositions and methods for treating cancer utilising oncolytic viruses, their components, and/or derivatives thereof. In particular, the invention relates to a modified Picornavirus comprising change(s) in one or more of its capsid proteins conferring enhanced binding capacity to cancer cells.
Claims71
A modified Picornavirus comprising change(s) in any one or more of capsid proteins:
- VP1, VP2, and VP3 compared to a wild-type strain of the virus, which confer enhanced binding capacity to decay accelerating factor (DAF/CD55) and/or Neonatal Fc Receptor (FcRn) compared to the wild-type strain.
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Dependencies are inferred from the claim text.