Compositions and methods for obtaining human intestinal tissue and related uses thereof
AssigneeThe Regents of the University of Michigan
InventorsMadeline Eiken, Charlie Childs, Jason Spence
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Abstract
The invention disclosed herein generally relates to methods and systems for converting stem cells into specific tissue(s) or organ(s) through directed differentiation. In particular, the invention disclosed herein relates to methods and systems for promoting human intestinal tissue (e.g., human intestinal organoid tissue) comprising epithelium, stroma, neurons, endothelial cells, and organized smooth muscle, and interstitial cells of Cajal (ICCs).
Claims8
A composition comprising human intestinal organoid tissue derived from human pluripotent stem cells, wherein the human intestinal organoid tissue comprises epithelial cells, stromal cells, neural cells, endothelial cells, smooth muscle cells, and interstitial cells of Cajal (ICCs).
Dependencies are inferred from the claim text.