Methods for the production of dendritic cells by modulating retinoid signaling
AssigneeFUJIFILM Holdings America Corporation
InventorsMaksym VODYANYK, Denise ALLARD TROUT, Kasey Nicole DAVIS, Xin ZHANG, Tasi Jo McFARLANE, Christopher McMAHON
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Abstract
Provided herein are methods for producing type 2 myeloid dendritic cells from hematopoietic progenitor cells (HPCs), such as induced pluripotent stem cell-derived HPCs, by induction with a retinoid signaling agonist, such as vitamin A.
Claims39
A method for producing conventional type 2 dendritic cells (cDC2) from hematopoietic progenitor cells (HPCs) comprising:
- (a) obtaining a population of HPCs;
- and
- (b) differentiating the HPCs in dendritic cell differentiation media comprising a retinoid signaling agonist to produce a population of cDC2.
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Dependencies are inferred from the claim text.