Systems and methods for bioprocessing
AssigneeMicrofluidX Ltd
InventorsCesare M. Cejas, Antonio de Grazia, Manjari Ghanshyam, James Kusena, Sreedhar Mareddy
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Abstract
The present disclosure provides systems and methods for bioprocessing. The systems and methods can be implemented using a chip (solid support comprising a bioprocessing chamber). The bioprocessing chamber can be fluidically connected to a feeding input channel. The chip can permit a fluid to flow from the feeding input channel through the bioprocessing chamber for cell seeding, perfusion, and/or expansion. The bioprocessing chamber can be in fluidic communication with a collection output. The cells can be harvested from the bioprocessing chamber through the collection output.
Claims20
A solid support comprising:
- a bioprocessing chamber comprising a first bottom surface for culturing cells and a first ceiling opposite of the first bottom surface, wherein the first bottom surface and the first ceiling are connected by one or more first sidewalls, wherein the bioprocessing chamber comprises a first height measured between the first bottom surface and the first ceiling;
- a feeding input channel configured to receive a fluid, wherein the feeding input channel is fluidically connected to the bioprocessing chamber, wherein the feeding input channel comprises a second bottom surface and a second ceiling opposite of the second bottom surface, wherein the second bottom surface and the second ceiling are connected by one or more second sidewalls, wherein the feeding input channel comprises a second height measured between the second bottom surface and the second ceiling of the feeding input channel, wherein the first bottom surface and the second bottom surface are parallel, and wherein the second height is less than the first height;
- and
- a feeding output channel fluidically connected to the bioprocessing chamber via the first ceiling.
Dependencies are inferred from the claim text.