Anti-tuberculosis vaccine targeting selected mycobacterium tuberculosis protective antigens to dendritic cells

An antibody that is directed against CD40 comprising:

• a heavy chain comprising the complementarity determining regions CDR1H, CDR2H and CDR3H, the CDR1H having the amino acid sequence GFTFSDYYMY (SEQ ID 5 NO:
• 1), the CDR2H having the amino acid sequence YINSGGGSTYYPDTVKG (SEQ ID NO:2), and the CDR3H having the amino acid sequence RGLPFHAMDY (SEQ ID NO:3),
• and a light chain comprising the complementarity determining regions CDR1L, CDR2L and CDR3L, the CDR1L having the amino acid sequence SASQGISNYLN (SEQ ID 10 NO:
• 4) the CDR2L having the amino acid sequence YTSILHS (SEQ ID NO:
• 5) and the CDR3L having the amino acid sequence QQFNKLPPT (SEQ ID NO:
• 6)
• and wherein the heavy chain is fused to the polyepitope polypeptide that comprises the Ag85B epitope as set forth in SEQ ID NO:7, the ESAT-6 epitope as set forth in SEQ ID NO:8 and the Mpt64 epitope as set forth in SEQ ID NO:9.