Human anti-trem2 antibody for treating neurodegenerative disorders
AssigneeISAR Bioscience GmbH
InventorsMiriam CHRISTLMEIER, Markus KRALLER, Hans-Peter HOLTHOFF, Martin UNGERER, Katrin SIMMNACHER
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Abstract
The invention provides a protein or antibody capable of binding to human TREM2, comprising an Ig light chain variable region and an Ig heavy chain variable region, wherein the amino acid sequence of the light chain variable region is that of SEQ ID NO: 1 or is an amino acid sequence having 1 or 2 amino acid residue substitutions compared to SEQ ID NO: 1, and the amino acid sequence of the heavy chain variable region is that of SEQ ID NO: 2 or is an amino acid sequence having 1 or 2 amino acid residue substitutions compared to SEQ ID NO: 2.
Claims28
A protein capable of binding to human TREM2, comprising or consisting of an immunoglobulin (Ig) heavy chain variable region, wherein the amino acid sequence of the heavy chain variable region is that of SEQ ID NO:
- 2 or is an amino acid sequence having 1 or 2 amino acid residue substitutions compared to SEQ ID NO:
- 2, wherein said protein is capable of activating human TREM2-dependent pSYK signaling.
A protein capable of binding to human TREM2, comprising or consisting of a heavy chain variable region and/or comprising or consisting of a light chain variable region, wherein
- the amino acid sequence of the heavy chain variable region is that of SEQ ID NO:
- 2 or is an amino acid sequence having 1 or 2 amino acid residue substitutions compared to SEQ ID NO:
- 2,
- the amino acid sequence of the light chain variable region is that of SEQ ID NO:
- 1 or is an amino acid sequence having 1 or 2 amino acid residue substitutions compared to SEQ ID NO:
- 1;
- wherein said protein is capable of activating human TREM2-dependent pSYK signaling.
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Dependencies are inferred from the claim text.