Anti-csp antibody variants
AssigneeAtreca, Inc.
InventorsDaniel Eric EMERLING, Katherine L. WILLIAMS, Steve GUERREO
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Abstract
The present disclosure provides anti-circumsporozoite (CSP) antibodies, compositions comprising such antibodies. Also disclosed are methods of producing the disclosed antibodies and methods of treating or preventing malaria using the same. Also disclosed are methods of selecting an antibody as an anti-malaria therapeutic antibody.
Claims32
A recombinant anti-circumsporozoite (CSP) antibody that binds to a first epitope present in the central repeat region of CSP and binds to a second epitope of CSP, wherein the first epitope comprises an amino acid sequence selected from SEQ ID NOs:
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A method of selecting an antibody as an anti-malaria therapeutic antibody, the method comprising:
- a) analyzing the antibody for binding to a first epitope of the central repeat region of CSP;
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- b) analyzing the antibody for binding to a second epitope of CSP that is heterologous to epitopes present in the RTS,S vaccine;
- wherein the antibody is selected if it binds to both the first epitope and the second epitope.
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Dependencies are inferred from the claim text.