Methods and compositions for gene transduction and to control the activity of synthetic and immune receptors
AssigneeAngeles Therapeutics, Inc.
InventorPreet M Chaudhary
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Abstract
The application provides novel viral envelope glycoproteins for pseudotyping viral vectors, novel designs for synthetic antigen receptors (SARs), novel signaling chains for construction of SARs, novel antigen binding domains, and novel methods for production of SAR-expressing cells. These novel methods and compositions have broad use in cellular therapy.
Claims24
A recombinant polynucleotide encoding at least one hybrid chain synthetic antigen receptor (HC-SAR) or a functional variant thereof, the at least one SAR or the functional variant comprising a heterodimer of two T-cell receptor (TCR) constant chains, the heterodimer having one or more non-TCR antigen binding domains that are operably linked to the TCR constant chains via optional linkers, wherein at least one TCR constant chain of the HC-SAR is a hybrid TCR chain, wherein the hybrid TCR chain comprises at least one domain selected from the group of domains consisting of a TCR chain constant domain (C), a TCR chain connecting peptide (ConnP), a TCR chain transmembrane (TM) domain, and a TCR chain cytoplasmic domain (CP) that is heterologous.
Dependencies are inferred from the claim text.