Use of mutant yap for improving cardiac function

Abstract

Provided is a modified Yes-associated protein (YAP) in which the serine residues of the LATS1/2 phosphorylation sites and a serine residue in the region of YAP that binds to TEAD are substituted with alanines. Also provided are nucleic acids encoding the modified YAP, vectors comprising the nucleic acids, and compositions comprising the modified YAP, nucleic acids encoding the modified YAP, or vectors comprising the nucleic acids. Further provided are methods of regenerating cardiomyocytes and of treating cardiac conditions.

Dependencies are inferred from the claim text.