Processes and intermediates for synthesis of adagrasib
AssigneeMirati Therapeutics, Inc.
InventorsTHOMAS SCATTOLIN, CHENG CHEN, YONGHONG GAN, CHENGSHENG CHEN, ZHICHAO LU
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Abstract
The present invention relates to new synthetic routes of synthesizing adagrasib. The invention also provides intermediates used in the provided synthetic routes.
Claims45
A method of synthesizing adagrasib, comprising step (a) of reacting a compound of the following structure:
- with a 4-halobutyrate, a aprotic solvent, an iodide, and a base to produce a final compound of step (a) with the following structure:
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A compound selected from the following structures:
Dependencies are inferred from the claim text.