Thiourea antioxcompounds with neuroprotective activity

A compound of the formula:

• wherein:
• X1 is O, S, or NRc, wherein Rc is hydrogen, alkyl(c≤8), or substituted alkyl(C≤8);
• R1, R1′, R2, and R2′ are each independently selected from hydrogen, alkyl(C≤12), or substituted alkyl(C≤12);
• R3 is hydroxy or an oxyl radical;
• Ra and Rb are each independently selected from hydrogen, alkyl(C≤6), or substituted alkyl(C≤6);
• Y is aryl(C≤12), substituted aryl(C≤12), heteroaryl(C≤12), substituted heteroaryl(C≤12), or a group of the formula:
• wherein:
• X2 is O, S(O)m, or NRa, wherein m is 0, 1, or 2;
• and Ra is hydrogen, alkyl(C≤6), or substituted alkyl(C≤6);
• and
• a and b are each independently 0, 1, 2, or 3;
• and
• x, y, and z are each independently 0, 1, 2, or 3;
• or a pharmaceutically acceptable salt thereof.