Continuous bioprocessing centrifuge rotor
OwnerSina PIRAMOONinventor
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OwnerSina PIRAMOONinventor
Estimating the term…
A rotor assembly (10, 150, 270, 310) and method of using the rotor assembly (10, 150, 270, 310). The rotor assembly (10, 150, 270, 310) includes a bio-process bag (48), a drum (46) that receives a lower portion of the bag (48), and a pressure ring (50). A holder (54, 182) couples an upper portion of the bag (48) to the pressure ring (50). The pressure ring (50) is coupled to the drum (46) to define an interior space that contains the bag (48). A liquid transport assembly (35, 178, 272) passes through an opening in the holder (54, 182) so that liquids can be added to, and removed from, the bag (48) without removing the rotor (16, 154) from the centrifuge. A bearing assembly (190) in the holder (54, 182) couples the liquid transport assembly (35, 178, 272) to the rotor (16, 154), and enables the liquid transport assembly (35, 178, 272) to remain stationary while the rotor (16, 154) rotates around it. One or more seal assemblies (276, 312) provide a fluid-tight seal against the outer portion of the liquid transport assembly (35, 178, 272), and prevent fluids from leaking from the bag (48) during centrifugation.
The method of claim 5, comprising removing the entirety of the first liquid medium from the rotor while the rotor is rotating at the second angular velocity.
The method of claim 5, wherein accelerating the rotor in one or more stages until the rotor reaches the first angular velocity comprises:
The method of claim 6, wherein decelerating the rotor in one or more stages until the rotor reaches the second angular velocity comprises:
A method of centrifuging a liquid medium including a first component and a second component, comprising:
Dependencies are inferred from the claim text.