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US 2026/0225099 A1Published application
Devices and methods for isolating extracellular vesicles
AssigneesThe Regents of the University of Michigan, Northwestern University
InventorsScott Smith, Sunitha Nagrath, Harika Lingamarla, Abha Kumari, Adam Mendel Sonabend Worthalter, Mark Youngblood
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Abstract
The present disclosure provides devices, systems, and methods for isolating extracellular vesicles utilizing extracellular vesicle capture agents. Particularly disclosed herein are devices, systems, and methods for isolating cancer-derived extracellular vesicles (e.g., meningioma (MGM)-specific extracellular vesicles).
Claims28
A microfluidic device for isolating extracellular vesicles comprising:
- an inlet;
- an outlet;
- and
- a plurality of wells distributed between and fluidly connected to the inlet and outlet,
- wherein each of the plurality of wells in fluid communication with two or more adjacent wells downstream of the inlet by a connecting channel, and
- wherein the plurality of wells, connecting channels, or a combination thereof are functionalized with an extracellular vesicle capture agent.
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Dependencies are inferred from the claim text.