Photobiomodulation and electrical modulation of a target area of the brain through an electro-optical cranial window

A system comprising:

• a first window configured to span through obstructive material of a skull of a patient between the skin and a precuneus of a hemisphere of a brain of the patient and comprising:
• a first electrode proximal the precuneus of the hemisphere to deliver an electrical stimulation, and
• a conductive pathway from a top of the window to the first electrode;
• a first electro-optical applicator comprising a light source and an electrical source and configured to align the light source with the first window to deliver a light signal through the first window to the precuneus of the hemisphere and the electrical source with the conductive pathway;
• a second window configured to span through obstructive material of the skull of the patient between the skin and another portion of the precuneus of the precuneus of the hemisphere or a portion of another precious of another hemisphere of the brain of the patient and comprising:
• a second electrode proximal the precuneus of the hemisphere to deliver an electrical stimulation, and
• another conductive pathway from a top of the window to the first electrode;
• and
• a second electro-optical applicator comprising another light source and another electrical source configured to align the other light source with the second window to deliver another light signal through the second window to the other portion of the precuneus or the other portion of the precuneus of the other hemisphere and the other electrical source with the other conductive pathway.