Wound dressing with tissue regeneration effect and wound dressing production method
AssigneeAfyonkarahisar Saglik Bilimleri Universitesi Ozel Kalem (Rektorluk)
InventorsFeyza Sevim ERDOGMUS, Nurullah OKUMUS, Ozlem Erdal ALTINTAS, Sefa CELIK
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Abstract
A wound dressing with tissue regeneration effect for medical use in the treatment of wounds and burns, which provides protection of the damaged tissue area from external influences and absorption of the damaged tissue fluid, as well as enhancement of tissue regeneration in the damaged tissue area, controlled release of bioactive components in the plant extract, reduction of pore size, while at the same time increasing water holding capacity and air permeability to accelerate healing of the damaged tissue, and a method of production of this wound dressing.
Claims11
A biocompatible and biodegradable wound dressing with tissue regeneration effect, which is suitable for use on a damaged tissue area, protecting the damaged tissue area from external influences, absorbing damaged tissue fluid, increases tissue regeneration in the damaged tissue area and the release of bioactive components in a controlled manner and the water holding capacity and air permeability while reducing the pore sizes in the structure, prevents the passage of bacteria and infection-causing substances into the damaged tissue and accelerating the healing process of the damaged tissue, the wound dressing comprising:
- at least one medical matrix comprising fungal-derived chitosan, wherein the fungal-derived chitosan is the form of nanofiber, which increases the efficiency of tissue regeneration in the damaged tissue area and controlled release of bioactive components, physically supports the cells in the healing process of the damaged tissue and provides adhesion of the cells by acting as a scaffold;
- at least one first bioactive component comprising Hypericum perforatum, wherein the Hypericum perforatum is in the form of nanoparticles integrated with the medical matrix, which enhances tissue regeneration and healing effects, treats damaged tissue, bacterial and viral infection with its antioxidant effect;
- and
- at least one second bioactive component comprising Cistus laurifolius, wherein the Cistus laurifolius is in the form of nanoparticles integrated with the medical matrix, which increases the healing efficiency of damaged tissue, provides antimicrobial, antioxidant and antiviral effect by creating a physical defense layer against bacteria and viruses on the damaged tissue with the polyphenols in it.
The method according to 6, wherein the fungi contain Rhizopus oryzae and/or Aspergillus brasiliensis.
The method according to 6, wherein the incubation process is executed at a temperature of 27° C.
The method according to 6, wherein the extraction process is executed at a temperature of 37° C.
The method according to 6, comprising the step of filtering the extracts by using filter paper.
The method according to 6, comprising the step of integrating the obtained nanoparticles into chitosan nanofibers by using the nozzle system of the electrostatic spinning device.
Dependencies are inferred from the claim text.