Methods Of Cellular Imaging And Inorganic Nanoimaging Agents For Same

A method of imaging of one or more bone(s) or any portion thereof, one or more musculoskeletal tissue(s) or any portion thereof, or any combination thereof in a sample or in an individual or a portion thereof, the method comprising:

• contacting the sample or the individual with a plurality of one or more inorganic nanoimaging agent(s), wherein each inorganic nanoimaging agent(s) of the plurality of inorganic nanoimaging agent(s) independently comprises one or more dye group(s), one or more sulfur atom group(s), one or more radioisotope group(s), one or more heavy atom group(s), one or more iodide group(s), or any combination thereof, wherein the dye group(s), the sulfur atom group(s), the radioisotope group(s), the heavy atom group(s), the iodide(s), or any combination thereof, if present, are independently disposed on a surface of an inorganic nanoimaging agent, covalently or non-covalently bonded to a matrix of the inorganic nanoimaging agent;
• directing excitation electromagnetic radiation into the sample or the individual, thereby exciting at least one of the one or more dye group(s), if present, one or more sulfur atom group(s), if present, one or more radioisotope group(s), if present, one or more heavy atom group(s), if present, one or more iodide group(s), if present, or the combination thereof resulting in excitation and emission of electromagnetic radiation from the one or more dye group(s), if present, one or more sulfur atom group(s), if present, one or more radioisotope group(s), if present, one or more heavy atom group(s), if present, one or more iodide group(s), if present, or the combination thereof;
• detecting at least a portion of the emitted electromagnetic radiation, the detected electromagnetic radiation having been emitted by the one or more dye group(s), if present, one or more sulfur atom group(s), if present, one or more radioisotope group(s), if present, one or more heavy atom group(s), if present, one or more iodide group(s), if present, or the combination thereof;
• and
• processing signals corresponding to the detected electromagnetic radiation to provide one or more image(s) of the bone(s) or the portion thereof, the musculoskeletal tissue(s) or the portion thereof, or the combination thereof in the sample, the individual, or the portion thereof.