Gene therapy for treating hearing loss disorders
AssigneeOhio Sate Innovation Foundation
InventorsKrystof BANKIEWICZ, Jerusha NAIDOO, Yin REN
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Abstract
Disclosed herein is a method of brainstem delivery of viral vectors in mammals to deliver transgenes to the inner ear via neuronal/axonal transport. This includes delivery of viral vectors to the cochlear nucleus (CN) and superior olivary complex (SOC), areas in the brainstem which send and receive neural inputs to and from the cochlea.
Claims17
A method for delivering a transgene to the inner ear, comprising administering a viral vector encoding the transgene to the cochlear nucleus and/or superior olivary complex of the subject, wherein the viral vector undergoes retrograde neuronal/axonal transport, anterograde neuronal/axonal transport, or a combination thereof.
A method for treating hearing loss in a subject, comprising administering a viral vector encoding a transgene that restores hearing to the cochlear nucleus and/or superior olivary complex of the subject.
Dependencies are inferred from the claim text.