Anti-cd45 antibody-drug conjugate pharmaceutical compositions
AssigneeRegeneron Pharmaceuticals, Inc.
InventorsAmit Katiyar, Kanyaphat Bunchongprasert, Prashant Bhattarai, Nicholas Yoder
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Abstract
Disclosed are pharmaceutical compositions comprising an antibody drug conjugate comprising anti-CD45 antibody conjugated to an indolinobenzodiazepine (IGN).
Claims31
A stable, pharmaceutical composition comprising an anti-CD45 antibody drug conjugate (ADC), a buffer, an antioxidant, a sugar, and a surfactant, wherein the ADC comprises a cytotoxin conjugated via a linker to an anti-CD45 antibody, wherein the anti-CD45 antibody comprises a heavy chain variable region comprising three heavy chain complimentary determining domains CDR1, CDR2, and CDR3 within the heavy chain variable region comprising the amino acid sequence set forth in SEQ ID NO:
- 1;
- and a light chain variable region comprising three light chain complimentary determining domains CDR1, CDR2, and CDR3 within the light chain variable region, wherein the light chain variable region comprising the amino acid sequence as set forth in SEQ ID NO:5.
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A stable, pharmaceutical composition comprising an anti-CD45 antibody drug conjugate (ADC), histidine, sodium bisulfite, sucrose, methionine and polysorbate 20, wherein the ADC comprises a cytotoxin conjugated via a linker to an anti-CD45 antibody, wherein the anti-CD45 antibody comprises a heavy chain variable region comprising a CDR1 domain comprising the amino acid sequence as set forth in SEQ ID NO:
- 2, a CDR2 domain comprising the amino acid sequence as set forth in SEQ ID NO:
- 3, and a CDR3 domain comprising the amino acid sequence as set forth in SEQ ID NO:
- 4;
- and comprises a light chain variable region comprising a CDR1 domain comprising the amino acid sequence as set forth in SEQ ID NO:
- 6, a CDR2 domain comprising the amino acid sequence as set forth in SEQ ID NO:
- 7, and a CDR3 domain comprising the amino acid sequence as set forth in SEQ ID NO:
- 8.
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Dependencies are inferred from the claim text.